A medication used to lower elevated LDL cholesterol by combining inhibition of cholesterol synthesis in the liver with reduced cholesterol absorption in the intestine.


Indications:
- Adjunct to diet for treating primary hypercholesterolemia (heterozygous familial and non-familial) or homozygous familial hypercholesterolemia.


Main Active Ingredients:
- Rosuvastatin (20 mg as rosuvastatin calcium).
- Ezetimibe (10 mg).

Precautions:
- Not suitable as initial therapy — only for patients stabilized on individual components.
- Monitor for muscle toxicity; contraindicated in conditions predisposing to myopathy/rhabdomyolysis (e.g., moderate renal impairment, hypothyroidism, prior statin muscle issues, etc.).
- Perform liver function tests before and 3 months after initiation; discontinue or adjust dose if transaminase levels ≥ 3× upper limit.
- Use with caution in patients with excessive alcohol consumption or liver disease.

Side Effects:
- Increased risk of myopathy and rhabdomyolysis with higher statin doses.
- Transaminase elevation, especially when combined with ezetimibe.
campus.

Drug–Drug Interactions:
- If co-administered with bile acid sequestrants, take Zympass ≥ 2 hours before or ≥ 4 hours after.

- Take one tablet daily, with or without food, as directed by a physician.

• Anti-hyperlipidemic

Rosuvastatin Calcium (Equivalent To 40 Mg Rosuvastatin) And Ezetimibe 10 Mg, Lactose Monohydrate, Microcrystalline Cellulose, Sodium Lauryl Sulfate, Hydroxypropyl Cellulose, Croscarmellose Sodium, Magnesium Stearate, Hypromellose, Macrogol (Polyethylene Glycol), Titanium Dioxide (E171), Talc.