A loop diuretic injection used for the rapid removal of excess fluid in conditions associated with edema and hypertension. It works by inhibiting sodium and chloride reabsorption in the loop of Henle, leading to increased urine output and reduced fluid overload.
Indications
- Edema due to congestive heart failure.
- Edema associated with liver cirrhosis.
- Renal diseaserelated edema (including nephrotic syndrome).
- Acute pulmonary edema.
- Management of hypertension (when rapid diuresis is required).
- Adjunct in cases of hypercalcemia.
Main Active Ingredient
- Furosemide (20 mg/2 mL, equivalent to 10 mg/mL).
Precautions:
- Contraindicated in patients with anuria or severe electrolyte depletion.
- Monitor electrolytes (especially potassium, sodium, calcium, magnesium).
- Use with caution in patients with hypotension or dehydration.
- Avoid in patients with severe hepatic coma or pre-coma states.
- Monitor renal function regularly during therapy.
- Risk of ototoxicity with rapid or high-dose intravenous use.
- Caution in elderly and patients with diabetes, gout, or hypotension.
- Avoid during pregnancy and lactation unless clearly necessary.
Side Effects:
- Increased urination.
- Dehydration.
- Electrolyte imbalance.
- Hypotension.
- Dizziness.
- Headache.
- Blurred vision.
- Muscle cramps.
- Weakness.
- Nausea.
- Vomiting.
- Ototoxicity
- Rash.
- Pruritus.
- Stevens-Johnson syndrome.
- Anaphylaxis.
Drug-Drug Interactions:
- Increased risk of hypokalemia with corticosteroids, laxatives, amphotericin B.
- Enhanced ototoxicity with aminoglycosides or cisplatin.
- Reduced effectiveness of antidiabetic drugs (may worsen hyperglycemia).
- Enhanced effect of antihypertensives (risk of severe hypotension).
- Lithium toxicity risk (reduced lithium clearance).
- NSAIDs may reduce diuretic and antihypertensive effects.
- Digoxin: hypokalemia increases risk of digitalis toxicity.
Furosemide,Sodium Chloride,Sodium Hydroxide,Water for Injections.