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A medication used to manage seizures and certain neurological or mood conditions by stabilizing neuronal activity via reducing repetitive firing in the brain, thereby preventing seizures and alleviating nerve pain.
Indications:
- Treatment of complex or simple partial seizures (with or without secondary generalization), generalized tonic-clonic seizures, and mixed seizure types.
- Acute mania and maintenance treatment of bipolar affective disorders to prevent recurrence.
- Alcohol-withdrawal syndrome.
- Idiopathic trigeminal neuralgia (and that due to multiple sclerosis), and idiopathic glossopharyngeal neuralgia.
- Painful diabetic neuropathy.
- Central diabetes insipidus (polyuria and polydipsia of neurohormonal origin).
Main Active Ingredient:
- Carbamazepine (modified-release) 200 mg per tablet.
Precautions:
- Not effective for absence (petit mal) and myoclonic seizures.
- Use with caution in patients with cardiovascular disease, hepatic or renal impairment, hematological disorders, glaucoma, or when switching from other antiepileptic drugs.
- Monitor for serious dermatologic reactions (e.g., Stevens–Johnson syndrome, toxic epidermal necrolysis), especially in patients with the HLA-B*1502 allele.
- Monitor blood counts for signs of bone marrow suppression (e.g., aplastic anemia, agranulocytosis).
Side Effects:
- Dizziness.
- Drowsiness.
- Nausea.
- Vomiting.
- Dry Mouth.
- Loss Of Balance Or Coordination.
- Severe Skin Reactions (SJS/TEN).
- Bone Marrow Depression (Aplastic Anemia, Agranulocytosis).
- Hyponatremia.
- SIADH.
- Hepatic Dysfunction.
- Renal Dysfunction.
- Cardiovascular Disturbances.
- Visual Disturbances.
- Increased Suicidal Ideation.
Drug-Drug Interactions:
- Potent inducer of CYP450 enzymes; can reduce the effectiveness of many drugs (e.g., warfarin, lamotrigine, benzodiazepines, theophylline, methadone) and hormonal contraceptives.
- Levels may be increased by CYP inhibitors (e.g., erythromycin, cimetidine, calcium channel blockers, grapefruit juice).
- Concomitant use with valproic acid may inhibit the metabolism of carbamazepine metabolite, increasing side effects.
Indications:
- Treatment of complex or simple partial seizures (with or without secondary generalization), generalized tonic-clonic seizures, and mixed seizure types.
- Acute mania and maintenance treatment of bipolar affective disorders to prevent recurrence.
- Alcohol-withdrawal syndrome.
- Idiopathic trigeminal neuralgia (and that due to multiple sclerosis), and idiopathic glossopharyngeal neuralgia.
- Painful diabetic neuropathy.
- Central diabetes insipidus (polyuria and polydipsia of neurohormonal origin).
Main Active Ingredient:
- Carbamazepine (modified-release) 200 mg per tablet.
Precautions:
- Not effective for absence (petit mal) and myoclonic seizures.
- Use with caution in patients with cardiovascular disease, hepatic or renal impairment, hematological disorders, glaucoma, or when switching from other antiepileptic drugs.
- Monitor for serious dermatologic reactions (e.g., Stevens–Johnson syndrome, toxic epidermal necrolysis), especially in patients with the HLA-B*1502 allele.
- Monitor blood counts for signs of bone marrow suppression (e.g., aplastic anemia, agranulocytosis).
Side Effects:
- Dizziness.
- Drowsiness.
- Nausea.
- Vomiting.
- Dry Mouth.
- Loss Of Balance Or Coordination.
- Severe Skin Reactions (SJS/TEN).
- Bone Marrow Depression (Aplastic Anemia, Agranulocytosis).
- Hyponatremia.
- SIADH.
- Hepatic Dysfunction.
- Renal Dysfunction.
- Cardiovascular Disturbances.
- Visual Disturbances.
- Increased Suicidal Ideation.
Drug-Drug Interactions:
- Potent inducer of CYP450 enzymes; can reduce the effectiveness of many drugs (e.g., warfarin, lamotrigine, benzodiazepines, theophylline, methadone) and hormonal contraceptives.
- Levels may be increased by CYP inhibitors (e.g., erythromycin, cimetidine, calcium channel blockers, grapefruit juice).
- Concomitant use with valproic acid may inhibit the metabolism of carbamazepine metabolite, increasing side effects.
Carbamazepine, Aerosil 200 (Colloidal Anhydrous Silica), Avicel PH 102 (Cellulose), Ethylcellulose Aqueous Dispersion, Eudragit ED (Polyacrylic/Methacrylic Ester Copolymer), Magnesium Stearate, Sodium CMC XL (Sodium Carboxymethyl Cellulose), And Talc. The Film-Coating Comprises Hydroxypropyl Methylcellulose HP-M 603, Cremophor RH 40 (Glyceryl Polyoxyethylene Glycol Stearate), Iron Oxide Red, Iron Oxide Yellow, Talc, And Titanium Dioxide
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