A medication used to lower elevated LDL cholesterol by combining inhibition of cholesterol synthesis in the liver with reduced cholesterol absorption in the intestine.


Indications:
- Adjunct to diet for treating primary hypercholesterolemia (heterozygous familial and non-familial) or homozygous familial hypercholesterolemia.


Main Active Ingredients:
- Rosuvastatin (40 mg as rosuvastatin calcium).
- Ezetimibe (10 mg).

Precautions:
- Not suitable as initial therapy — only for patients stabilized on individual components.
- Monitor for muscle toxicity; contraindicated in conditions predisposing to myopathy/rhabdomyolysis (e.g., moderate renal impairment, hypothyroidism, prior statin muscle issues, etc.).
- Perform liver function tests before and 3 months after initiation; discontinue or adjust dose if transaminase levels ≥ 3× upper limit.
- Use with caution in patients with excessive alcohol consumption or liver disease.

Side Effects:
- Increased risk of myopathy and rhabdomyolysis with higher statin doses.
- Transaminase elevation, especially when combined with ezetimibe.
campus.

Drug–Drug Interactions:
- If co-administered with bile acid sequestrants, take Zympass ≥ 2 hours before or ≥ 4 hours after.