This medication is a combination medication that contains two active ingredients: glyburide and metformin hydrochloride. Each tablet of Glucovance 500mg/5mg includes 500 mg of metformin and 5 mg of glyburide. This formulation is specifically designed for the management of type 2 diabetes mellitus in adults, particularly when diet and exercise alone do not provide adequate glycemic control.

-Benefits:
-Dual Mechanism of Action: The combination of glyburide and metformin works synergistically to lower blood sugar levels. Glyburide, a sulfonylurea, stimulates the pancreas to release more insulin, which helps lower blood glucose levels. Metformin decreases glucose production in the liver and improves insulin sensitivity, allowing the body to use insulin more effectively.
-Improved glycemic control for patients can achieve better overall control of their blood sugar levels compared to using either medication alone. This can lead to improved HbA1c levels (a measure of long-term blood sugar control) and reduced fasting plasma glucose levels.
-Effective management of blood sugar levels with Glucovance can help prevent or delay the onset of complications associated with diabetes, such as kidney damage, nerve problems, vision loss, and cardiovascular issues.
-Taking a single tablet that combines two medications simplifies the treatment regimen for patients, making it easier to adhere to prescribed therapy compared to taking multiple separate medications.
-Metformin is often associated with weight neutrality or modest weight loss in patients with type 2 diabetes, which can be beneficial for individuals who are overweight or obese.
-While hypoglycemia (low blood sugar) can occur with glyburide use, the risk is generally lower when it is combined with metformin due to metformin’s mechanism that does not cause insulin release on its own.

-Main Ingredients & Their Benefits:
-Metformin Hydrochloride (500 mg) is a biguanide that lowers blood glucose by reducing hepatic glucose production, increasing insulin sensitivity, delaying intestinal glucose absorption, and improving lipid metabolism.
-Glibenclamide (5 mg) is a second-generation sulfonylurea that stimulates insulin secretion from the pancreas, enhances postprandial insulin response, and works complementarily with metformin to address both insulin resistance and insufficient insulin secretion in patients with type 2 diabetes.

-Precautions:
-Before using Glucovance, inform your doctor about any of the following conditions:
-Recent injury, surgery, or infection with fever.
-Liver or kidney issues.
-G6PD enzyme deficiency.
-Heart disease.
-If you are pregnant, breastfeeding, or planning to become pregnant, consult your doctor before taking Glucovance. Your doctor will weigh the risks and benefits of using the medication during pregnancy or breastfeeding
-Also, tell your doctor about all other medications, including prescriptions, over-the-counter drugs, herbal supplements, and vitamins.
-Store below 25°C and avoid refrigeration.
-Keep the medication out of reach of children and in its original packaging to protect it from moisture.
-Do not use after the expiry date listed on the packaging.

-Side Effects:
-A decrease in blood cells (platelets, red or white blood cells).
-Nausea, diarrhea.
-Vision problems.
-Allergic reactions.
-Low blood sugar.
-Liver issues.