An orally disintegrating medication used to prevent nausea and vomiting by selectively blocking 5-HT3 receptors in the central nervous system and gastrointestinal tract.
Indications:
- Prevention of chemotherapy-induced nausea and vomiting (high or moderate emetogenic risk).
- Prevention of radiotherapy-induced nausea and vomiting.
- Prevention of postoperative nausea and vomiting.
Main Active Ingredient:
- Ondansetron 8 mg.
Precautions:
- Avoid in patients with hypersensitivity to ondansetron or any component of the formulation.
- Use with caution in patients with congenital long QT syndrome or electrolyte abnormalities.
- Monitor for signs of serotonin syndrome when used with other serotonergic drugs.
- Monitor for myocardial ischemia after oral administration.
- Avoid masking of progressive ileus or gastric distension following abdominal surgery or chemotherapy.
- Contains phenylalanine; inform patients with phenylketonuria.
Side Effects:
- Headache, malaise, fatigue, constipation, diarrhea.
- Hypoxia (in postoperative use).
- Rare hypersensitivity reactions, including anaphylaxis and bronchospasm.
Drug-Drug Interactions:
- Avoid concurrent use with apomorphine (used in Parkinson’s disease).
- Use with caution with serotonergic medications such as fluoxetine, paroxetine, sertraline, citalopram, escitalopram, venlafaxine, and duloxetine.
- Use with caution with drugs that prolong the QT interval, such as amiodarone, sotalol, quinidine, procainamide, erythromycin, clarithromycin, haloperidol, ziprasidone, and methadone.
Ondansetron, Hypromellose, Iron Oxide Yellow, Lactose, Magnesium Stearate, Microcrystalline Cellulose, Pregelatinized Starch, Triacetin, Titanium Dioxide.